Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study.

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  • Additional Information
    • Author-Supplied Keywords:
      colon cancer
      epidemiology
      GSTM1
      GSTT1
      rectum cancer
    • Abstract:
      BACKGROUND: GSTM1 and GSTT1 are phase II enzymes which provide chemical defense to cells. OBJECTIVE: This study was designed to evaluate association of GSTM1 and GSTT1 deletion along with epidemiological factors with risk of colon and rectum cancers. METHODOLOGY: Multiplex PCR was used for cancer patients as well as age and gender matched cancer free controls. RESULTS: Mean age of patients and controls was 45.5 (± 14.6) and 43.5 (± 18.08) years respectively. Among epidemiological factors; gender, age ≥ 50 years, active/passive smoking, naswar addiction, residential area, family history, red meat, fruit and vegetable intake showed no association with CRC (P ≥ 0.05). Symptoms of CRC like altered bowel habits (70%) was more common compared with other symptoms. GSTM1 (P ≤ 0.05) and GSTT1 (P ≤ 0.05) deletions were found to be significantly associated with CRC compared with controls. Association of epidemiological factors like gender, active/passive smoking, naswar addiction, residential area and family history were associated neither with GSTM1 deletion nor to GSTT1 deletion in both cancers (P ≤ 0.05). Significant association was present between stage III and GSTM1 (CI 95% 0.15-1.39) as well as GSTT1 (CI 95% 0.14-2.44) deletion in CRC. CONCLUSION: These results suggest that GSTM1 and GSTT1 deletion were associated with increased risk of colon and rectum cancer in Pakistani population. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Environmental Sciences, Fatima Jinnah Women University, Mall, Rawalpindi, Pakistan
    • ISSN:
      1574-0153
    • Accession Number:
      10.3233/CBM-150498
    • Accession Number:
      109375283
  • Citations
    • ABNT:
      MASOOD, N.; MUBASHAR, A.; YASMIN, A. Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study. Cancer Biomarkers, [s. l.], v. 15, n. 5, p. 583–589, 2015. Disponível em: . Acesso em: 25 ago. 2019.
    • AMA:
      Masood N, Mubashar A, Yasmin A. Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study. Cancer Biomarkers. 2015;15(5):583-589. doi:10.3233/CBM-150498.
    • APA:
      Masood, N., Mubashar, A., & Yasmin, A. (2015). Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study. Cancer Biomarkers, 15(5), 583–589. https://doi.org/10.3233/CBM-150498
    • Chicago/Turabian: Author-Date:
      Masood, Nosheen, Aroosha Mubashar, and Azra Yasmin. 2015. “Epidemiological Factors Related to GSTM1 and GSTT1 Genes Deletion in Colon and Rectum Cancers: A Case-Control Study.” Cancer Biomarkers 15 (5): 583–89. doi:10.3233/CBM-150498.
    • Harvard:
      Masood, N., Mubashar, A. and Yasmin, A. (2015) ‘Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study’, Cancer Biomarkers, 15(5), pp. 583–589. doi: 10.3233/CBM-150498.
    • Harvard: Australian:
      Masood, N, Mubashar, A & Yasmin, A 2015, ‘Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study’, Cancer Biomarkers, vol. 15, no. 5, pp. 583–589, viewed 25 August 2019, .
    • MLA:
      Masood, Nosheen, et al. “Epidemiological Factors Related to GSTM1 and GSTT1 Genes Deletion in Colon and Rectum Cancers: A Case-Control Study.” Cancer Biomarkers, vol. 15, no. 5, Sept. 2015, pp. 583–589. EBSCOhost, doi:10.3233/CBM-150498.
    • Chicago/Turabian: Humanities:
      Masood, Nosheen, Aroosha Mubashar, and Azra Yasmin. “Epidemiological Factors Related to GSTM1 and GSTT1 Genes Deletion in Colon and Rectum Cancers: A Case-Control Study.” Cancer Biomarkers 15, no. 5 (September 2015): 583–89. doi:10.3233/CBM-150498.
    • Vancouver/ICMJE:
      Masood N, Mubashar A, Yasmin A. Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study. Cancer Biomarkers [Internet]. 2015 Sep [cited 2019 Aug 25];15(5):583–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=109375283&custid=s8280428