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Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer.

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  • Additional Information
    • Author-Supplied Keywords:
      colorectal cancer
      Cullin1
      diagnosis
      MMP-2
      prognosis
    • Abstract:
      BACKGROUND: Cullin1 and MMP-2 have been identified as important markers in various cancers, but their roles in colorectal cancer (CRC) have remained to be discovered. The aim of this study was to investigate the expression pattern and significance of Cullin1 and MMP-2 in CRC. METHODS: A total of 470 CRC patients were enrolled. Archival paraffin-embedded CRC tissue samples were used to generate tissue microarray blocks, which were immunohistochemically stained for Cullin1 and MMP-2. Prognostic and predictive role of Cullin1 and MMP-2 expression was evaluated by univariate and multivariate analysis, respectively. Values of p < 0.05 were considered statistically significant. RESULTS: Cullin1 and MMP-2 protein levels were significantly upregulated in CRC tissues compared with adjacent noncancerous tissues. High tumoral Cullin1 orMMP-2 expression significantly correlated with shorter overall survival (OS), as well as with clinicopathologic characteristics in patients. Multivariate regression analysis showed that high Cullin1 and MMP-2 expressions, separately and together, were independent negative markers of OS. CONCLUSION: Cullin1 and MMP-2 expressions could be novel diagnostic and prognostic markers for CRC patients. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Oncology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China
      2Department of Pathology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China
      3Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China
    • ISSN:
      1574-0153
    • Accession Number:
      10.3233/CBM-160341
    • Accession Number:
      123001252
  • Citations
    • ABNT:
      JIANLIANG DENG et al. Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer. Cancer Biomarkers, [s. l.], v. 19, n. 1, p. 57–64, 2017. DOI 10.3233/CBM-160341. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=123001252&custid=s8280428. Acesso em: 3 jul. 2020.
    • AMA:
      Jianliang Deng, Wenjiao Chen, Yuan Du, et al. Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer. Cancer Biomarkers. 2017;19(1):57-64. doi:10.3233/CBM-160341.
    • AMA11:
      Jianliang Deng, Wenjiao Chen, Yuan Du, et al. Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer. Cancer Biomarkers. 2017;19(1):57-64. doi:10.3233/CBM-160341
    • APA:
      Jianliang Deng, Wenjiao Chen, Yuan Du, Weiming Wang, Guoqiang Zhang, Yuehua Tang, Zhangjun Qian, Ping Xu, Zhihong Cao, & Yan Zhou. (2017). Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer. Cancer Biomarkers, 19(1), 57–64. https://doi.org/10.3233/CBM-160341
    • Chicago/Turabian: Author-Date:
      Jianliang Deng, Wenjiao Chen, Yuan Du, Weiming Wang, Guoqiang Zhang, Yuehua Tang, Zhangjun Qian, Ping Xu, Zhihong Cao, and Yan Zhou. 2017. “Synergistic Efficacy of Cullin1 and MMP-2 Expressions in Diagnosis and Prognosis of Colorectal Cancer.” Cancer Biomarkers 19 (1): 57–64. doi:10.3233/CBM-160341.
    • Harvard:
      Jianliang Deng et al. (2017) ‘Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer’, Cancer Biomarkers, 19(1), pp. 57–64. doi: 10.3233/CBM-160341.
    • Harvard: Australian:
      Jianliang Deng, Wenjiao Chen, Yuan Du, Weiming Wang, Guoqiang Zhang, Yuehua Tang, Zhangjun Qian, Ping Xu, Zhihong Cao & Yan Zhou 2017, ‘Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer’, Cancer Biomarkers, vol. 19, no. 1, pp. 57–64, viewed 3 July 2020, .
    • MLA:
      Jianliang Deng, et al. “Synergistic Efficacy of Cullin1 and MMP-2 Expressions in Diagnosis and Prognosis of Colorectal Cancer.” Cancer Biomarkers, vol. 19, no. 1, July 2017, pp. 57–64. EBSCOhost, doi:10.3233/CBM-160341.
    • Chicago/Turabian: Humanities:
      Jianliang Deng, Wenjiao Chen, Yuan Du, Weiming Wang, Guoqiang Zhang, Yuehua Tang, Zhangjun Qian, Ping Xu, Zhihong Cao, and Yan Zhou. “Synergistic Efficacy of Cullin1 and MMP-2 Expressions in Diagnosis and Prognosis of Colorectal Cancer.” Cancer Biomarkers 19, no. 1 (July 2017): 57–64. doi:10.3233/CBM-160341.
    • Vancouver/ICMJE:
      Jianliang Deng, Wenjiao Chen, Yuan Du, Weiming Wang, Guoqiang Zhang, Yuehua Tang, et al. Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer. Cancer Biomarkers [Internet]. 2017 Jul [cited 2020 Jul 3];19(1):57–64. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=123001252&custid=s8280428