Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia.

Item request has been placed! ×
Item request cannot be made. ×
  Processing Request
  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      Demography
      ocular surface squamous neoplasia
    • Abstract:
      Purpose: The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN).Methods: This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year.Results: The median age of presentation was 55 years with male:female ratio being 4.5:1. Systemic predisposing conditions were xeroderma pigmentosa (1) postkidney transplant immunosuppression (1), and human immunodeficiency virus infection (1). Patients with predisposing conditions had a younger median age of onset (33 years). The majority of tumors were nodular (61.4%), gelatinous (61.4%), and had limbal involvement (96%). On ultrasound biomicroscopy (UBM), mean tumor height was 2.93 ± 1.02 mm, and intraocular extension was evident in seven eyes. OSSN with intraocular extension had a mean tumor height of 4.3 ± 1.32 mm. Nodal metastasis was seen in one case at presentation. As per American Joint Committee for Cancer Classification seventh edition staging-two cases were T1, one was T2, 46 were T3 and eight were T4. Treatment advised included conservative therapy for 39; wide local excision (4 mm margin clearance) with cryotherapy for seven; enucleation in four; and exenteration in four eyes. Overall, complete regression was achieved in 88% of cases during a mean follow-up of 13.5 ± 4.6 months. Recurrence was seen in three cases, which were treated with exenteration, radical neck dissection, and palliative chemo-radiotherapy, respectively.Conclusion: Although associated with old age, earlier onset of OSSN is seen in patients with systemic predisposing conditions. Thicker tumors in the setting of a previous surgery or immunocompromised status should be considered high-risk features for intraocular extension and should be evaluated on UBM. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Indian Journal of Ophthalmology is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    • ISSN:
      0301-4738
    • Accession Number:
      10.4103/ijo.IJO_251_17
    • Accession Number:
      125737810
  • Citations
    • ABNT:
      MEEL, R. et al. Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian Journal of Ophthalmology, [s. l.], v. 65, n. 10, p. 936–941, 2017. Disponível em: . Acesso em: 16 nov. 2019.
    • AMA:
      Meel R, Dhiman R, Vanathi M, Pushker N, Tandon R, Devi S. Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian Journal of Ophthalmology. 2017;65(10):936-941. doi:10.4103/ijo.IJO_251_17.
    • APA:
      Meel, R., Dhiman, R., Vanathi, M., Pushker, N., Tandon, R., & Devi, S. (2017). Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian Journal of Ophthalmology, 65(10), 936–941. https://doi.org/10.4103/ijo.IJO_251_17
    • Chicago/Turabian: Author-Date:
      Meel, Rachna, Rebika Dhiman, Murugesan Vanathi, Neelam Pushker, Radhika Tandon, and Saranya Devi. 2017. “Clinicodemographic Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia.” Indian Journal of Ophthalmology 65 (10): 936–41. doi:10.4103/ijo.IJO_251_17.
    • Harvard:
      Meel, R. et al. (2017) ‘Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia’, Indian Journal of Ophthalmology, 65(10), pp. 936–941. doi: 10.4103/ijo.IJO_251_17.
    • Harvard: Australian:
      Meel, R, Dhiman, R, Vanathi, M, Pushker, N, Tandon, R & Devi, S 2017, ‘Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia’, Indian Journal of Ophthalmology, vol. 65, no. 10, pp. 936–941, viewed 16 November 2019, .
    • MLA:
      Meel, Rachna, et al. “Clinicodemographic Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia.” Indian Journal of Ophthalmology, vol. 65, no. 10, Oct. 2017, pp. 936–941. EBSCOhost, doi:10.4103/ijo.IJO_251_17.
    • Chicago/Turabian: Humanities:
      Meel, Rachna, Rebika Dhiman, Murugesan Vanathi, Neelam Pushker, Radhika Tandon, and Saranya Devi. “Clinicodemographic Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia.” Indian Journal of Ophthalmology 65, no. 10 (October 2017): 936–41. doi:10.4103/ijo.IJO_251_17.
    • Vancouver/ICMJE:
      Meel R, Dhiman R, Vanathi M, Pushker N, Tandon R, Devi S. Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian Journal of Ophthalmology [Internet]. 2017 Oct [cited 2019 Nov 16];65(10):936–41. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=125737810&custid=s8280428