Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids.

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  • Additional Information
    • Author-Supplied Keywords:
      Animal models
      Animal studies
      Bacteria
      Bacterial pathogens
      Biology and life sciences
      Cancers and neoplasms
      Carcinogenesis
      Carcinomas
      Clostridium
      Diet
      Experimental organism systems
      Gastroenterology and hepatology
      Gastrointestinal tumors
      Genetics
      Genomics
      Gut bacteria
      Hepatocellular carcinoma
      Liver diseases
      Medical microbiology
      Medicine and health sciences
      Microbial genomics
      Microbial pathogens
      Microbiology
      Microbiome
      Model organisms
      Mouse models
      Nutrition
      Oncology
      Opinion
      Organisms
      Pathogens
      Pathology and laboratory medicine
      Research and analysis methods
    • Abstract:
      The cause of liver cancer in cross-fostered WT mice supported the function of gut microbiota in soluble fiber-induced liver cancer. Taken together, these data highlight the role of the gut microbiota in fiber-induced liver cancer in mice and further demonstrate that the liver cancer-inducing bacteria are transmissible. As the gut microbiota is one of the drivers of carcinogenesis in patients with liver cancer, clostridia harboring the I bai i operon can be considered a promising target for liver cancer prevention. It is therefore accepted that the gut microbiota influences hepatic innate immunity via the gut-liver axis; accordingly, gut microbiota is considered to potentially affect the efficacy of immunotherapies against liver cancer. [Extracted from the article]
    • Abstract:
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    • Author Affiliations:
      1School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China
      2Department of Life Science, Chung-Ang University, Seoul, Republic of Korea
    • Full Text Word Count:
      5244
    • ISSN:
      1553-7366
    • Accession Number:
      10.1371/journal.ppat.1007954
    • Accession Number:
      138448217
  • Citations
    • ABNT:
      JIA, B.; JEON, C. O. Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids. PLoS Pathogens, [s. l.], v. 15, n. 9, p. 1–9, 2019. Disponível em: . Acesso em: 22 out. 2019.
    • AMA:
      Jia B, Jeon CO. Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids. PLoS Pathogens. 2019;15(9):1-9. doi:10.1371/journal.ppat.1007954.
    • APA:
      Jia, B., & Jeon, C. O. (2019). Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids. PLoS Pathogens, 15(9), 1–9. https://doi.org/10.1371/journal.ppat.1007954
    • Chicago/Turabian: Author-Date:
      Jia, Baolei, and Che Ok Jeon. 2019. “Promotion and Induction of Liver Cancer by Gut Microbiome-Mediated Modulation of Bile Acids.” PLoS Pathogens 15 (9): 1–9. doi:10.1371/journal.ppat.1007954.
    • Harvard:
      Jia, B. and Jeon, C. O. (2019) ‘Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids’, PLoS Pathogens, 15(9), pp. 1–9. doi: 10.1371/journal.ppat.1007954.
    • Harvard: Australian:
      Jia, B & Jeon, CO 2019, ‘Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids’, PLoS Pathogens, vol. 15, no. 9, pp. 1–9, viewed 22 October 2019, .
    • MLA:
      Jia, Baolei, and Che Ok Jeon. “Promotion and Induction of Liver Cancer by Gut Microbiome-Mediated Modulation of Bile Acids.” PLoS Pathogens, vol. 15, no. 9, Sept. 2019, pp. 1–9. EBSCOhost, doi:10.1371/journal.ppat.1007954.
    • Chicago/Turabian: Humanities:
      Jia, Baolei, and Che Ok Jeon. “Promotion and Induction of Liver Cancer by Gut Microbiome-Mediated Modulation of Bile Acids.” PLoS Pathogens 15, no. 9 (September 5, 2019): 1–9. doi:10.1371/journal.ppat.1007954.
    • Vancouver/ICMJE:
      Jia B, Jeon CO. Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids. PLoS Pathogens [Internet]. 2019 Sep 5 [cited 2019 Oct 22];15(9):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=138448217&custid=s8280428