Cellulases: ambiguous nonhomologous enzymes in a genomic perspective

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  • Additional Information
    • NAICS/Industry Codes:
      541711 Research and Development in Biotechnology
    • Abstract:
      The key material for bioethanol production is cellulose, which is one of the main components of the plant cell wall. Enzymatic depolymerization of cellulose is an essential step in bioethanol production, and can be accomplished by fungal and bacterial cellulases. Most of the biochemically characterized bacterial cellulases come from only a few cellulose-degrading bacteria, thus limiting our knowledge of a range of cellulolytic activities that exist in nature. The recent explosion of genomic data offers a unique opportunity to search for novel cellulolytic activities; however, the absence of clear understanding of structural and functional features that are important for reliable computational identification of cellulases precludes their exploration in the genomic datasets. Here, we explore the diversity of cellulases and propose a genomic approach to overcome this bottleneck. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
      2Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
      3Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN 37996, USA
      4Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
      5Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    • ISSN:
      0167-7799
    • Accession Number:
      10.1016/j.tibtech.2011.04.008
    • Accession Number:
      65493295
  • Citations
    • ABNT:
      SUKHARNIKOV, L. O. et al. Cellulases: ambiguous nonhomologous enzymes in a genomic perspective. Trends in Biotechnology, [s. l.], v. 29, n. 10, p. 473–479, 2011. Disponível em: . Acesso em: 20 out. 2019.
    • AMA:
      Sukharnikov LO, Cantwell BJ, Podar M, Zhulin IB. Cellulases: ambiguous nonhomologous enzymes in a genomic perspective. Trends in Biotechnology. 2011;29(10):473-479. doi:10.1016/j.tibtech.2011.04.008.
    • APA:
      Sukharnikov, L. O., Cantwell, B. J., Podar, M., & Zhulin, I. B. (2011). Cellulases: ambiguous nonhomologous enzymes in a genomic perspective. Trends in Biotechnology, 29(10), 473–479. https://doi.org/10.1016/j.tibtech.2011.04.008
    • Chicago/Turabian: Author-Date:
      Sukharnikov, Leonid O., Brian J. Cantwell, Mircea Podar, and Igor B. Zhulin. 2011. “Cellulases: Ambiguous Nonhomologous Enzymes in a Genomic Perspective.” Trends in Biotechnology 29 (10): 473–79. doi:10.1016/j.tibtech.2011.04.008.
    • Harvard:
      Sukharnikov, L. O. et al. (2011) ‘Cellulases: ambiguous nonhomologous enzymes in a genomic perspective’, Trends in Biotechnology, 29(10), pp. 473–479. doi: 10.1016/j.tibtech.2011.04.008.
    • Harvard: Australian:
      Sukharnikov, LO, Cantwell, BJ, Podar, M & Zhulin, IB 2011, ‘Cellulases: ambiguous nonhomologous enzymes in a genomic perspective’, Trends in Biotechnology, vol. 29, no. 10, pp. 473–479, viewed 20 October 2019, .
    • MLA:
      Sukharnikov, Leonid O., et al. “Cellulases: Ambiguous Nonhomologous Enzymes in a Genomic Perspective.” Trends in Biotechnology, vol. 29, no. 10, Oct. 2011, pp. 473–479. EBSCOhost, doi:10.1016/j.tibtech.2011.04.008.
    • Chicago/Turabian: Humanities:
      Sukharnikov, Leonid O., Brian J. Cantwell, Mircea Podar, and Igor B. Zhulin. “Cellulases: Ambiguous Nonhomologous Enzymes in a Genomic Perspective.” Trends in Biotechnology 29, no. 10 (October 2011): 473–79. doi:10.1016/j.tibtech.2011.04.008.
    • Vancouver/ICMJE:
      Sukharnikov LO, Cantwell BJ, Podar M, Zhulin IB. Cellulases: ambiguous nonhomologous enzymes in a genomic perspective. Trends in Biotechnology [Internet]. 2011 Oct [cited 2019 Oct 20];29(10):473–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=65493295&custid=s8280428