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Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma.

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  • Additional Information
    • Author-Supplied Keywords:
      diagnosis
      Glycomics
      N-glycan
      non-small cell lung carcinoma
      plasma
    • Abstract:
      Successful therapy of the non-small cell lung carcinoma (NSCLC) depends on its early detection, and non-invasive detection methods are preferred. As plasma proteins are modified by N-linked glycosylation, we tested the importance of the N-glycan profile in diagnosing and prognosticating NSCLC. We analysed desialylated plasma samples from 75 NSCLC patients, and 71 healthy individuals by the high-throughput DNA sequencer-based carbohydrate analytical profiling technique. We detected alterations in the levels of several N-glycans in NSCLC patients. Total α-1,6-core fucosylated biantennaries (NGA2F, NG1A2F, NA2F) and total bisecting α-1,6-core fucosylated biantennaries (NGA2FB, NA2FB) were reduced in NSCLC patients, whereas the branching α-1,3-fucosylated triantennary N-glycan (NA3FB) was increased. Best diagnostic accuracy was identified for NG1A2F. NSCLC patients with TNM stage I stage did not show further differences, but patients with higher stages did (TNM II to IV). Those patients additionally had a reduced level in the α-1,6-core fucosylated structure NA2F with parallel increase in the non-fucosylated structure NA2. In this regard, NSCLC patients with a relatively low amount of NA2 per NA2F had a better three-year survival than patients with high amount. NSCLC patients show an altered N-glycan profile of plasma proteins that may be regarded as a supportive tool for cancer diagnosis. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Cardio-thoracic Surgery, University Hospital Halle (Saale), Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
      2Department for Molecular Biomedical Research, VIB, Ghent, Belgium
      3Department of Biomedical Molecular Research, Ghent University, Ghent, Belgium
      4Department of Thoracic Surgery, Hospital Barmherzige Brüder Regensburg, Regensburg, Germany
      5Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
      6Department of Medicine III, University Hospital Halle (Saale), Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
    • ISSN:
      1574-0153
    • Accession Number:
      10.3233/CBM-2012-0239
    • Accession Number:
      76349611
  • Citations
    • ABNT:
      BARTLING, B. et al. Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomarkers, [s. l.], v. 10, n. 3/4, p. 145–154, 2012. DOI 10.3233/CBM-2012-0239. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=76349611&custid=s8280428. Acesso em: 4 jul. 2020.
    • AMA:
      Bartling B, Vanhooren V, Dewaele S, et al. Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomarkers. 2012;10(3/4):145-154. doi:10.3233/CBM-2012-0239.
    • AMA11:
      Bartling B, Vanhooren V, Dewaele S, et al. Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomarkers. 2012;10(3/4):145-154. doi:10.3233/CBM-2012-0239
    • APA:
      Bartling, B., Vanhooren, V., Dewaele, S., Libert, C., Hofmann, H.-S., Haerting, J., Nuding, S., Silber, R.-E., Simm, A., & Chen, C. C. (2012). Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomarkers, 10(3/4), 145–154. https://doi.org/10.3233/CBM-2012-0239
    • Chicago/Turabian: Author-Date:
      Bartling, Babett, Valerie Vanhooren, Sylviane Dewaele, Claude Libert, Hans-Stefan Hofmann, Johannes Haerting, Sebastian Nuding, Rolf-Edgar Silber, Andreas Simm, and Cuiying Chitty Chen. 2012. “Altered Desialylated Plasma N-Glycan Profile in Patients with Non-Small Cell Lung Carcinoma.” Cancer Biomarkers 10 (3/4): 145–54. doi:10.3233/CBM-2012-0239.
    • Harvard:
      Bartling, B. et al. (2012) ‘Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma’, Cancer Biomarkers, 10(3/4), pp. 145–154. doi: 10.3233/CBM-2012-0239.
    • Harvard: Australian:
      Bartling, B, Vanhooren, V, Dewaele, S, Libert, C, Hofmann, H-S, Haerting, J, Nuding, S, Silber, R-E, Simm, A & Chen, CC 2012, ‘Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma’, Cancer Biomarkers, vol. 10, no. 3/4, pp. 145–154, viewed 4 July 2020, .
    • MLA:
      Bartling, Babett, et al. “Altered Desialylated Plasma N-Glycan Profile in Patients with Non-Small Cell Lung Carcinoma.” Cancer Biomarkers, vol. 10, no. 3/4, May 2012, pp. 145–154. EBSCOhost, doi:10.3233/CBM-2012-0239.
    • Chicago/Turabian: Humanities:
      Bartling, Babett, Valerie Vanhooren, Sylviane Dewaele, Claude Libert, Hans-Stefan Hofmann, Johannes Haerting, Sebastian Nuding, Rolf-Edgar Silber, Andreas Simm, and Cuiying Chitty Chen. “Altered Desialylated Plasma N-Glycan Profile in Patients with Non-Small Cell Lung Carcinoma.” Cancer Biomarkers 10, no. 3/4 (May 2012): 145–54. doi:10.3233/CBM-2012-0239.
    • Vancouver/ICMJE:
      Bartling B, Vanhooren V, Dewaele S, Libert C, Hofmann H-S, Haerting J, et al. Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomarkers [Internet]. 2012 May [cited 2020 Jul 4];10(3/4):145–54. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=76349611&custid=s8280428