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Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma.

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  • Additional Information
    • Author-Supplied Keywords:
      clinico-pathological parameters
      Human fetal thyroid
      immunohistochemistry
      matrix metalloproteinase-2
      papillary thyroid carcinoma
      tissue inhibitors of matrix metalloproteinase-2
    • Abstract:
      Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have roles in physiological and pathological processes. We evaluated immunohistochemical expression of MMP-2 and TIMP-2 in paraffin sections of 12 human fetal thyroids at mid-term gestation and 79 thyroid tumors of follicular origin. Besides evaluating expression of these proteins during fetal development and neoplastic transformation, we determined whether expression of MMP-2 and TIMP-2 may help to differentiate papillary thyroid carcinoma (PTC) from follicular thyroid adenoma (FTA) and/or peritumoral tissue (PT). We also investigated their relationship with prognostically important clinicopathological parameters of PTC. Immunoreactive MMP-2 and TIMP-2 were found in all fetal thyroid tissues examined. Tumor tissues contained variable amounts of MMP-2 and TIMP-2, with overexpression of these proteins in PTC compared to FTA and PT tissue. According to the statistical analysis, MMP-2 distinguished follicular variant of PTC from FTA and overall PTC from total nonmalignant lesions. In PTC, high MMP-2 expression correlated with lymph node metastasis (P=0.022), while high TIMP-2 expression was positively correlated with tumor size (P=0.049) and extrathyroid invasion (P=0.017). Overall, these results indicate a role for MMP-2 and TIMP-2 in both thyroid development and malignant transformation and suggest that positive immunohistochemistry for MMP-2 and TIMP-2 might support diagnosis of PTC and predict unfavorable biological behavior. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Zemun-Belgrade, Serbia
      2Institute of Pathology, School of Medicine, University of Belgrade, Belgrade, Serbia
      3Institute of Medical Chemistry, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
      4Center for Endocrine Surgery, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia
      5School of Medicine, Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia
    • ISSN:
      1574-0153
    • Accession Number:
      10.3233/CBM-2012-0258
    • Accession Number:
      77873912
  • Citations
    • ABNT:
      MAREĈKO, I. et al. Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma. Cancer Biomarkers, [s. l.], v. 11, n. 1, p. 49–58, 2012. DOI 10.3233/CBM-2012-0258. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=77873912&custid=s8280428. Acesso em: 3 jul. 2020.
    • AMA:
      Mareĉko I, Cvejić D, Tatić S, Dragutinović V, Paunović I, Savin S. Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma. Cancer Biomarkers. 2012;11(1):49-58. doi:10.3233/CBM-2012-0258.
    • AMA11:
      Mareĉko I, Cvejić D, Tatić S, Dragutinović V, Paunović I, Savin S. Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma. Cancer Biomarkers. 2012;11(1):49-58. doi:10.3233/CBM-2012-0258
    • APA:
      Mareĉko, I., Cvejić, D., Tatić, S., Dragutinović, V., Paunović, I., & Savin, S. (2012). Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma. Cancer Biomarkers, 11(1), 49–58. https://doi.org/10.3233/CBM-2012-0258
    • Chicago/Turabian: Author-Date:
      Mareĉko, Ilona, Dubravka Cvejić, Svetislav Tatić, Vesna Dragutinović, Ivan Paunović, and Svetlana Savin. 2012. “Expression of Matrix Metalloproteinase-2 and Its Tissue Inhibitor-2 in Fetal and Neoplastic Thyroid Tissue and Their Significance as Diagnostic and Prognostic Markers in Papillary Carcinoma.” Cancer Biomarkers 11 (1): 49–58. doi:10.3233/CBM-2012-0258.
    • Harvard:
      Mareĉko, I. et al. (2012) ‘Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma’, Cancer Biomarkers, 11(1), pp. 49–58. doi: 10.3233/CBM-2012-0258.
    • Harvard: Australian:
      Mareĉko, I, Cvejić, D, Tatić, S, Dragutinović, V, Paunović, I & Savin, S 2012, ‘Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma’, Cancer Biomarkers, vol. 11, no. 1, pp. 49–58, viewed 3 July 2020, .
    • MLA:
      Mareĉko, Ilona, et al. “Expression of Matrix Metalloproteinase-2 and Its Tissue Inhibitor-2 in Fetal and Neoplastic Thyroid Tissue and Their Significance as Diagnostic and Prognostic Markers in Papillary Carcinoma.” Cancer Biomarkers, vol. 11, no. 1, Nov. 2012, pp. 49–58. EBSCOhost, doi:10.3233/CBM-2012-0258.
    • Chicago/Turabian: Humanities:
      Mareĉko, Ilona, Dubravka Cvejić, Svetislav Tatić, Vesna Dragutinović, Ivan Paunović, and Svetlana Savin. “Expression of Matrix Metalloproteinase-2 and Its Tissue Inhibitor-2 in Fetal and Neoplastic Thyroid Tissue and Their Significance as Diagnostic and Prognostic Markers in Papillary Carcinoma.” Cancer Biomarkers 11, no. 1 (November 2012): 49–58. doi:10.3233/CBM-2012-0258.
    • Vancouver/ICMJE:
      Mareĉko I, Cvejić D, Tatić S, Dragutinović V, Paunović I, Savin S. Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma. Cancer Biomarkers [Internet]. 2012 Nov [cited 2020 Jul 3];11(1):49–58. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=77873912&custid=s8280428