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NPRL2 is an independent prognostic factor of osteosarcoma.

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  • Additional Information
    • Author-Supplied Keywords:
      immunohistochemistry
      NPRL2
      Osteosarcoma
      prognosis
    • Abstract:
      NPRL2 is a tumor suppressor gene whose inactivation contributes to tumor development. However, NPRL2 expression in osteosarcoma remains unclear. This study aimed to assess NPRL2 expression in osteosarcoma and analyze its potential as a prognostic factor. NPRL2 expression in 48 cases of osteosarcoma and 40 cases of osteochondroma tumors was examined by immunohistochemistry. NPRL2 expression in 20 osteosarcoma and 20 osteochondroma specimens were detected by Real-time PCR and Western blot analysis. We found that 18 cases (37.5%) of osteosarcoma and 27 cases (67.5%) of osteochondroma showed positive NPRL2 expression. Real-Time PCR and Western blot analysis showed that NRPL2 expression was lower in osteosarcoma than in osteochondroma (p< 0.05). The positive rate of NPRL2 expression was 71.4% (10/14), 25% (4/16) and 16.7% (3/18) in stage I, II and III of osteosarcoma, respectively. The positive rate of NPRL2 was 19% (4/21) and 48.1% (13/27) for low grade and high grade of osteosarcoma, respectively, with significant difference (p< 0.05). Cox multivariate analysis showed that the value of NPRL2 for predicting the overall survival of osteosarcoma patients. Despite the small size of the samples, our results suggest that NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Orthopedics, The First Affiliated Hospital, Liaoning Medical University, Jinzhou, Liaoning, China
      2The second Hospital of Jinzhou, Jinzhou, Liaoning, China
      3Department of Orthopedics, First Affiliated Hospital of China Medial University, Shenyang, China
    • ISSN:
      1574-0153
    • Accession Number:
      10.3233/CBM-120290
    • Accession Number:
      84761033
  • Citations
    • ABNT:
      GAO, Y.; WANG, J.; FAN, G. NPRL2 is an independent prognostic factor of osteosarcoma. Cancer Biomarkers, [s. l.], v. 12, n. 1, p. 31–36, 2013. DOI 10.3233/CBM-120290. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=84761033&custid=s8280428. Acesso em: 3 jul. 2020.
    • AMA:
      Gao Y, Wang J, Fan G. NPRL2 is an independent prognostic factor of osteosarcoma. Cancer Biomarkers. 2013;12(1):31-36. doi:10.3233/CBM-120290.
    • AMA11:
      Gao Y, Wang J, Fan G. NPRL2 is an independent prognostic factor of osteosarcoma. Cancer Biomarkers. 2013;12(1):31-36. doi:10.3233/CBM-120290
    • APA:
      Gao, Y., Wang, J., & Fan, G. (2013). NPRL2 is an independent prognostic factor of osteosarcoma. Cancer Biomarkers, 12(1), 31–36. https://doi.org/10.3233/CBM-120290
    • Chicago/Turabian: Author-Date:
      Gao, Yuzhong, Jian Wang, and Guangyu Fan. 2013. “NPRL2 Is an Independent Prognostic Factor of Osteosarcoma.” Cancer Biomarkers 12 (1): 31–36. doi:10.3233/CBM-120290.
    • Harvard:
      Gao, Y., Wang, J. and Fan, G. (2013) ‘NPRL2 is an independent prognostic factor of osteosarcoma’, Cancer Biomarkers, 12(1), pp. 31–36. doi: 10.3233/CBM-120290.
    • Harvard: Australian:
      Gao, Y, Wang, J & Fan, G 2013, ‘NPRL2 is an independent prognostic factor of osteosarcoma’, Cancer Biomarkers, vol. 12, no. 1, pp. 31–36, viewed 3 July 2020, .
    • MLA:
      Gao, Yuzhong, et al. “NPRL2 Is an Independent Prognostic Factor of Osteosarcoma.” Cancer Biomarkers, vol. 12, no. 1, Jan. 2013, pp. 31–36. EBSCOhost, doi:10.3233/CBM-120290.
    • Chicago/Turabian: Humanities:
      Gao, Yuzhong, Jian Wang, and Guangyu Fan. “NPRL2 Is an Independent Prognostic Factor of Osteosarcoma.” Cancer Biomarkers 12, no. 1 (January 2013): 31–36. doi:10.3233/CBM-120290.
    • Vancouver/ICMJE:
      Gao Y, Wang J, Fan G. NPRL2 is an independent prognostic factor of osteosarcoma. Cancer Biomarkers [Internet]. 2013 Jan [cited 2020 Jul 3];12(1):31–6. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=84761033&custid=s8280428