Stable isotope ratios in hair and teeth reflect biologic rhythms.

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    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
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    • Abstract:
      Biologic rhythms give insight into normal physiology and disease. They can be used as biomarkers for neuronal degenerations. We present a diverse data set to show that hair and teeth contain an extended record of biologic rhythms, and that analysis of these tissues could yield signals of neurodegenerations. We examined hair from mummified humans from South America, extinct mammals and modern animals and people, both healthy and diseased, and teeth of hominins. We also monitored heart-rate variability, a measure of a biologic rhythm, in some living subjects and analyzed it using power spectra. The samples were examined to determine variations in stable isotope ratios along the length of the hair and across growth-lines of the enamel in teeth. We found recurring circa-annual periods of slow and fast rhythms in hydrogen isotope ratios in hair and carbon and oxygen isotope ratios in teeth. The power spectra contained slow and fast frequency power, matching, in terms of normalized frequency, the spectra of heart rate variability found in our living subjects. Analysis of the power spectra of hydrogen isotope ratios in hair from a patient with neurodegeneration revealed the same spectral features seen in the patient's heart-rate variability. Our study shows that spectral analysis of stable isotope ratios in readily available tissues such as hair could become a powerful diagnostic tool when effective treatments and neuroprotective drugs for neurodegenerative diseases become available. It also suggests that similar analyses of archaeological specimens could give insight into the physiology of ancient people and animals.
    • References:
      Science. 2006 Aug 4;313(5787):644-9. (PMID: 16809488)
      Science. 2006 Nov 10;314(5801):980-2. (PMID: 17095699)
      Science. 2006 Nov 24;314(5803):1304-8. (PMID: 17124323)
      Hypertension. 2007 Jan;49(1):120-6. (PMID: 17101845)
      Science. 2006 Dec 22;314(5807):1941-4. (PMID: 17185605)
      Nature. 1985 Oct 10-16;317(6037):525-7. (PMID: 19093314)
      Lancet Neurol. 2006 Jul;5(7):572-7. (PMID: 16781987)
      J Endocrinol. 2003 Apr;177(1):17-26. (PMID: 12697033)
      Circulation. 1991 Aug;84(2):482-92. (PMID: 1860193)
      J Comp Neurol. 1997 Sep 29;386(3):379-95. (PMID: 9303424)
      N Engl J Med. 1999 Aug 12;341(7):491-7. (PMID: 10441606)
      Semin Cutan Med Surg. 2006 Mar;25(1):2-10. (PMID: 16616298)
      Science. 2001 Jul 20;293(5529):506-9. (PMID: 11441147)
    • Contributed Indexing:
      Note: Original DateCompleted: 20070802
    • Accession Number:
      0 (Nitrogen Isotopes)
      0 (Oxygen Isotopes)
    • Publication Date:
      Date Created: 20070727 Date Completed: 20100423 Latest Revision: 20181113
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