Simultaneous synthesis of treatment effects and mapping to a common scale: an alternative to standardisation.

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  • Additional Information
    • Source:
      Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101543738 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-2887 (Electronic) Linking ISSN: 17592879 NLM ISO Abbreviation: Res Synth Methods Subsets: MEDLINE
    • Publication Information:
      Publication: : Chichester : Wiley Blackwell
      Original Publication: Malden, MA : John Wiley & Sons, 2010-
    • Subject Terms:
      Meta-Analysis as Topic* ; Treatment Outcome*; Biostatistics/*methods; Anxiety Disorders/drug therapy ; Clinical Trials as Topic/standards ; Clinical Trials as Topic/statistics & numerical data ; Databases, Factual/statistics & numerical data ; Humans ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Social Behavior Disorders/drug therapy
    • Abstract:
      Objective: Trials often may report several similar outcomes measured on different test instruments. We explored a method for synthesising treatment effect information both within and between trials and for reporting treatment effects on a common scale as an alternative to standardisation
      Study Design: We applied a procedure that simultaneously estimates a pooled treatment effect and the "mapping" ratios between the treatment effects on test instruments in a connected network. Standardised and non-standardised treatment effects were compared. The methods were illustrated in a dataset of 22 trials of selective serotonin reuptake inhibitors against placebo for social anxiety disorder, each reporting treatment effects on between one and six of a total nine test instruments.
      Results: Ratios of treatment effects on different test instruments varied from trial to trial, with a coefficient of variation of 18% (95% credible interval 11-29%). Standardised effect models fitted the data less well, and standardised treatment effects were estimated with less relative precision than non-standardised effects and with greater relative heterogeneity.
      Conclusion: Simultaneous synthesis of treatment effects and mapping to a common scale make fewer assumptions than standardising by dividing effects by the sample standard deviation, allow results to be reported on a common scale, and deliver estimates with superior relative precision.
      (© 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.)
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    • Grant Information:
      G0901488 United Kingdom MRC_ Medical Research Council; MC_U145079307 United Kingdom MRC_ Medical Research Council; MR/M005232/1 United Kingdom MRC_ Medical Research Council
    • Contributed Indexing:
      Keywords: evidence synthesis; mapping; multiple outcomes; social anxiety
    • Accession Number:
      0 (Serotonin Uptake Inhibitors)
    • Publication Date:
      Date Created: 20150603 Date Completed: 20160425 Latest Revision: 20221207
    • Publication Date:
      20221216
    • Accession Number:
      PMC4433769
    • Accession Number:
      10.1002/jrsm.1130
    • Accession Number:
      26035473