Network meta-analysis including treatment by covariate interactions: Consistency can vary across covariate values.

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    • Source:
      Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101543738 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-2887 (Electronic) Linking ISSN: 17592879 NLM ISO Abbreviation: Res Synth Methods Subsets: MEDLINE
    • Publication Information:
      Publication: : Chichester : Wiley Blackwell
      Original Publication: Malden, MA : John Wiley & Sons, 2010-
    • Subject Terms:
    • Abstract:
      Background: Many reviews aim to compare numerous treatments and report results stratified by subgroups (eg, by disease severity). In such cases, a network meta-analysis model including treatment by covariate interactions can estimate the relative effects of all treatment pairings for each subgroup of patients. Two key assumptions underlie such models: consistency of treatment effects and consistency of the regression coefficients for the interactions. Consistency may differ depending on the covariate value at which consistency is assessed. For valid inference, we need to be confident of consistency for the relevant range of covariate values. In this paper, we demonstrate how to assess consistency of treatment effects from direct and indirect evidence at various covariate values.
      Methods: Consistency is assessed using visual inspection, inconsistency estimates, and probabilities. The method is applied to an individual patient dataset comparing artemisinin combination therapies for treating uncomplicated malaria in children using the covariate age.
      Results: The magnitude of the inconsistency appears to be decreasing with increasing age for each comparison. For one comparison, direct and indirect evidence differ for age 1 (P = .05), and this brings results for age 1 for all comparisons into question.
      Conclusion: When fitting models including interactions, the consistency of direct and indirect evidence must be assessed across the range of covariates included in the trials. Clinical inferences are only valid for covariate values for which results are consistent.
      (© 2017 The Authors. Research Synthesis Methods published by John Wiley & Sons Ltd.)
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    • Grant Information:
      MR/M005615/1 United Kingdom MRC_ Medical Research Council; MR/P015298/1 United Kingdom MRC_ Medical Research Council; MR/K025643/1 United Kingdom MRC_ Medical Research Council; MR/M005232/1 United Kingdom MRC_ Medical Research Council; MC_UP_A900_1119 United Kingdom MRC_ Medical Research Council; MR/K021435/1 United Kingdom MRC_ Medical Research Council
    • Contributed Indexing:
      Keywords: consistency; indirect comparison; individual patient data; meta-regression; mnetwork meta-analysis; treatment by covariate interaction
    • Accession Number:
      0 (Artemisinins)
      9RMU91N5K2 (artemisinin)
    • Publication Date:
      Date Created: 20170722 Date Completed: 20180806 Latest Revision: 20210915
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