Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel : MDPI, c2004-
    • Subject Terms:
    • Abstract:
      Increased mortality due to malignant mesothelioma has been demonstrated by several epidemiologic studies in the area around Broni (a small town in Lombardy, northern Italy), where a factory producing asbestos cement was active between 1932 and 1993. Until now, the inorganic fiber burden in lungs has not been investigated in this population. The aim of this study is to assess the lung fiber burden in 72 individuals with previous occupational and/or anthropogenic environmental exposure to asbestos during the activity of an important asbestos cement factory. Inorganic fiber lung burden was assessed in autoptic samples taken from individuals deceased from asbestos-related diseases using a scanning electron microscope equipped with an energy-dispersive spectrometer. Significant differences in the detected amount of asbestos were pointed out among the three types of exposure. In most lung samples taken from patients who died of mesothelioma, very little asbestos (or, in some cases, no fibers) was found. Such subjects showed a significantly lower median amount of asbestos as compared to asbestosis. Almost no chrysotile was detected in the examined samples. Overall, crocidolite was the most represented asbestos, followed by amosite, tremolite/actinolite asbestos, and anthophyllite asbestos. There were significant differences in the amount of crocidolite and amosite fibers according to the kind of exposure. Overall, these findings provide novel insights into the link between asbestos exposure and mesothelioma, as well as the different impacts of the various types of asbestos on human health in relation to their different biopersistences in the lung microenvironment.
    • Comments:
      Comment in: Int J Environ Res Public Health. 2021 Jul 05;18(13):. (PMID: 34281114)
      Comment in: Int J Environ Res Public Health. 2021 Jul 05;18(13):. (PMID: 34281119)
    • References:
      Environ Res. 2020 Apr;183:108968. (PMID: 31812249)
      Chest. 1988 Mar;93(3):621-8. (PMID: 2830081)
      Br J Ind Med. 1980 Feb;37(1):25-32. (PMID: 7370190)
      Am J Ind Med. 1999 Apr;35(4):401-12. (PMID: 10086201)
      Eur J Epidemiol. 2000 May;16(5):411-7. (PMID: 10997827)
      Occup Environ Med. 2017 Nov;74(11):838-846. (PMID: 28935666)
      Ann Occup Hyg. 1994 Aug;38(4):625-33, 424-5. (PMID: 7978985)
      Occup Environ Med. 2016 May;73(5):290-9. (PMID: 26715106)
      Occup Environ Med. 1998 Dec;55(12):840-6. (PMID: 9924446)
      Ann Occup Hyg. 2015 Aug;59(7):909-21. (PMID: 25878166)
      Int J Occup Environ Health. 2007 Jan-Mar;13(1):64-9. (PMID: 17427350)
      Eur Respir J. 2017 Jun 29;49(6):. (PMID: 28663314)
      Occup Environ Med. 2015 Sep;72(9):648-55. (PMID: 26045315)
      Cancer. 1994 Apr 1;73(7):1825-35. (PMID: 8137206)
      Am Rev Respir Dis. 1985 Jul;132(1):143-7. (PMID: 4014859)
      Am Rev Respir Dis. 1984 Dec;130(6):1042-5. (PMID: 6095707)
      Exp Lung Res. 1988;14(5):567-74. (PMID: 2852101)
      Curr Opin Pulm Med. 2014 Jul;20(4):366-70. (PMID: 24811832)
      Environ Int. 2015 Jan;74:191-9. (PMID: 25454236)
      Ann Occup Hyg. 2000 Dec;44(8):565-601. (PMID: 11108782)
      Crit Rev Toxicol. 2013 Feb;43(2):154-83. (PMID: 23346982)
      Environ Pollut. 2020 Aug;263(Pt B):114384. (PMID: 32234644)
      Environ Health Perspect. 1994 Oct;102 Suppl 5:229-33. (PMID: 7882939)
      Am J Respir Crit Care Med. 1994 Sep;150(3):663-9. (PMID: 8087335)
      Am J Ind Med. 1992;22(1):49-58. (PMID: 1329506)
      Ann Work Expo Health. 2020 Mar 10;64(3):297-310. (PMID: 32065212)
      Cancer. 1991 Apr 1;67(7):1912-20. (PMID: 1848472)
      Am J Ind Med. 2017 Oct;60(10):852-866. (PMID: 28833303)
      J Public Health Res. 2018 Dec 20;7(3):1519. (PMID: 30687679)
      Am J Respir Crit Care Med. 2008 Sep 15;178(6):624-9. (PMID: 18556631)
      Ann Occup Hyg. 2012 Jul;56(6):660-70. (PMID: 22247179)
      Toxicol Appl Pharmacol. 2020 Jan 15;387:114856. (PMID: 31836523)
      Environ Health Perspect. 2007 Jul;115(7):1066-71. (PMID: 17637924)
      Regul Toxicol Pharmacol. 2008 Oct;52(1 Suppl):S223-31. (PMID: 18022298)
      Br Med J (Clin Res Ed). 1982 Aug 28-Sep 4;285(6342):603-6. (PMID: 6297656)
      Ultrastruct Pathol. 2016 May-Jun;40(3):126-33. (PMID: 26934117)
      CA Cancer J Clin. 2019 Sep;69(5):402-429. (PMID: 31283845)
      Am J Ind Med. 1993 Apr;23(4):605-14. (PMID: 8480769)
      Epidemiol Prev. 2016 Sep-Oct;40(5Suppl1):19-98. (PMID: 27825198)
      IARC Sci Publ. 1989;(90):438-43. (PMID: 2545616)
      Occup Environ Med. 2016 Sep;73(9):607-13. (PMID: 27312399)
      Ann Occup Hyg. 1994 Aug;38(4):601-15, 421-2. (PMID: 7978983)
      Cancer. 1989 Apr 15;63(8):1544-7. (PMID: 2924262)
      Crit Rev Toxicol. 2008;38 Suppl 1:49-73. (PMID: 18686078)
      Recent Results Cancer Res. 2011;189:79-95. (PMID: 21479897)
      Med Lav. 2014 Jan-Feb;105(1):15-29. (PMID: 24552091)
      Eur Respir J. 1998 Jun;11(6):1416-26. (PMID: 9657589)
      J Toxicol Environ Health A. 2016;79(3):129-41. (PMID: 26818092)
      Scand J Work Environ Health. 2015 Jan;41(1):5-15. (PMID: 25299403)
      Transl Lung Cancer Res. 2020 Feb;9(Suppl 1):S39-S46. (PMID: 32206569)
    • Contributed Indexing:
      Keywords: SEM-EDS*; asbestos*; asbestos bodies*; lung fiber burden*; malignant mesothelioma*
    • Accession Number:
      1332-21-4 (Asbestos)
    • Publication Date:
      Date Created: 20210306 Date Completed: 20210426 Latest Revision: 20210730
    • Publication Date:
      20220301
    • Accession Number:
      PMC7923219
    • Accession Number:
      10.3390/ijerph18042053
    • Accession Number:
      33669843