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Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections

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  • Additional Information
    • Affiliation:
      a Department of Pharmaceutics, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, P.O.B 12065, Jerusalem 91120, Israel
      b Biofilm Research Laboratory, Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, P.O.B 12272, Jerusalem 91120, Israel
      c Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O.B. 12, Rehovot 76100, Israel
    • Keywords:
      Thiazolidinedione-8
      Quorum sensing
      Catheter-associated infections
      Varnish
      Modeling
      Sustained release
    • Abstract:
      Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs’ therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit® RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.
    • ISSN:
      0378-5173
    • Accession Number:
      10.1016/j.ijpharm.2015.02.067
    • Accession Number:
      S0378517315001957
    • Copyright:
      Copyright © 2015 Elsevier B.V. All rights reserved.
  • Citations
    • ABNT:
      SHENDEROVICH, J. et al. Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections. International Journal of Pharmaceutics, [s. l.], v. 485, n. 1–2, p. 164–170, 2015. DOI 10.1016/j.ijpharm.2015.02.067. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0378517315001957&custid=s8280428. Acesso em: 20 fev. 2020.
    • AMA:
      Shenderovich J, Feldman M, Kirmayer D, et al. Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections. International Journal of Pharmaceutics. 2015;485(1-2):164-170. doi:10.1016/j.ijpharm.2015.02.067.
    • APA:
      Shenderovich, J., Feldman, M., Kirmayer, D., Al-Quntar, A., Steinberg, D., Lavy, E., & Friedman, M. (2015). Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections. International Journal of Pharmaceutics, 485(1–2), 164–170. https://doi.org/10.1016/j.ijpharm.2015.02.067
    • Chicago/Turabian: Author-Date:
      Shenderovich, Julia, Mark Feldman, David Kirmayer, Abed Al-Quntar, Doron Steinberg, Eran Lavy, and Michael Friedman. 2015. “Local Sustained-Release Delivery Systems of the Antibiofilm Agent Thiazolidinedione-8 for Prevention of Catheter-Associated Urinary Tract Infections.” International Journal of Pharmaceutics 485 (1–2): 164–70. doi:10.1016/j.ijpharm.2015.02.067.
    • Harvard:
      Shenderovich, J. et al. (2015) ‘Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections’, International Journal of Pharmaceutics, 485(1–2), pp. 164–170. doi: 10.1016/j.ijpharm.2015.02.067.
    • Harvard: Australian:
      Shenderovich, J, Feldman, M, Kirmayer, D, Al-Quntar, A, Steinberg, D, Lavy, E & Friedman, M 2015, ‘Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections’, International Journal of Pharmaceutics, vol. 485, no. 1–2, pp. 164–170, viewed 20 February 2020, .
    • MLA:
      Shenderovich, Julia, et al. “Local Sustained-Release Delivery Systems of the Antibiofilm Agent Thiazolidinedione-8 for Prevention of Catheter-Associated Urinary Tract Infections.” International Journal of Pharmaceutics, vol. 485, no. 1–2, May 2015, pp. 164–170. EBSCOhost, doi:10.1016/j.ijpharm.2015.02.067.
    • Chicago/Turabian: Humanities:
      Shenderovich, Julia, Mark Feldman, David Kirmayer, Abed Al-Quntar, Doron Steinberg, Eran Lavy, and Michael Friedman. “Local Sustained-Release Delivery Systems of the Antibiofilm Agent Thiazolidinedione-8 for Prevention of Catheter-Associated Urinary Tract Infections.” International Journal of Pharmaceutics 485, no. 1–2 (May 15, 2015): 164–70. doi:10.1016/j.ijpharm.2015.02.067.
    • Vancouver/ICMJE:
      Shenderovich J, Feldman M, Kirmayer D, Al-Quntar A, Steinberg D, Lavy E, et al. Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections. International Journal of Pharmaceutics [Internet]. 2015 May 15 [cited 2020 Feb 20];485(1–2):164–70. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0378517315001957&custid=s8280428