BackgroundIn Indian medical treatments, the extracts from plants and leaves played major role in pharmaceuticals drugs. Objective of the present study is to find the anti-immunodeficiency pills by the herbal solution. MethodsNatural medicine in this is to prepare the anti-immunodeficiency tablet from the neem leaf, guava leaf and the high vitamin content pomegranate leaf. The mixed extract of all three leaf phytochemicals and which can use as an anti-immunodeficiency tablet. To extract the ingredients from the leaves the process of infusion has been followed and then the extract converted to powder as per standard procedure. Result and ConclusionThe produced herbal combinations have been characterized by the FTIR, XRD, FESEM with EDAX (EDS) and antimicrobial testing and the results is analysed.